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首页> 外文OA文献 >The role of calcium supplementation in healthy musculoskeletal ageing : An expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF).
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The role of calcium supplementation in healthy musculoskeletal ageing : An expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF).

机译：钙补充剂在健康的骨骼肌肉老化中的作用：欧洲骨质疏松症，骨关节炎和肌肉骨骼疾病的临床和经济方面学会（ESCEO）和国际骨质疏松基金会（IOF）的专家共识会议。

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The place of calcium supplementation, with or without concomitant vitamin D supplementation, has been much debated in terms of both efficacy and safety. There have been numerous trials and meta-analyses of supplementation for fracture reduction, and associations with risk of myocardial infarction have been suggested in recent years. In this report, the product of an expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF), we review the evidence for the value of calcium supplementation, with or without vitamin D supplementation, for healthy musculoskeletal ageing. We conclude that: 1) calcium and vitamin D supplementation leads to a modest reduction in fracture risk, although population-level intervention has not been shown to be an effective public health strategy; 2) supplementation with calcium alone for fracture reduction is not supported by the literature; 3) side effects of calcium supplementation include renal stones and gastrointestinal symptoms; 4) vitamin D supplementation, rather than calcium supplementation, may reduce falls risk; and 5) assertions of increased cardiovascular risk consequent on calcium supplementation are not convincingly supported by current evidence. In conclusion, we recommend, on the basis of the current evidence, that calcium supplementation, with concomitant vitamin D supplementation, is supported for patients at high risk of calcium and vitamin D insufficiency, and in those who are receiving treatment for osteoporosis.
机译：就功效和安全性而言，补充钙与不伴随维生素D补充的位置一直存在争议。已有许多关于减少骨折的补充剂的试验和荟萃分析，并且近年来已提出与心肌梗塞风险的关联。在本报告中，这是欧洲骨质疏松症，骨关节炎和肌肉骨骼疾病临床和经济方面专家协会（ESCEO）和国际骨质疏松基金会（IOF）的专家共识会议的产物，我们审查了补充钙的价值的证据，无论是否添加维生素D，均可使肌肉骨骼健康老化。我们得出以下结论：1）尽管尚未证明在人群一级进行干预是一种有效的公共卫生策略，但补充钙和维生素D可使骨折风险适度降低； 2）文献仅支持补充钙以减少骨折。 3）补钙的副作用包括肾结石和胃肠道症状； 4）补充维生素D而不是补充钙可以降低跌倒的风险； 5）目前的证据不能令人信服地支持因补充钙导致心血管风险增加的说法。总之，我们建议根据目前的证据，对钙和维生素D功能不足的高风险患者以及正在接受骨质疏松症治疗的患者，建议同时补充钙和维生素D。

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